GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BRCA | cis | rs7637404 | 1 | rs11710136 | chr3:190985993 | UTS2D | chr3:190984945-191048325:- | -0.22 | -6.49 | 1.34E-10 | Age-related hearing impairment (interaction) |
| BRCA | cis | rs1853207 | 1 | rs117104023 | chr10:96515342 | C10orf129 | chr10:96953957-96988685:+ | 0.33 | 5.38 | 9.15E-8 | Blood metabolite levels |
| BRCA | cis | rs7647973 | 1 | rs11710434 | chr3:49346130 | AMT | chr3:49454212-49460012:- | 0.13 | 4.58 | 5.14E-6 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11710434 | chr3:49346130 | CCDC36 | chr3:49235861-49295537:+ | 0.1 | 3.93 | 9.18E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11710434 | chr3:49346130 | NCKIPSD | chr3:48711280-48723334:- | 0.17 | 4.22 | 2.61E-5 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11710434 | chr3:49346130 | P4HTM | chr3:49027341-49044579:+ | 0.1 | 4.45 | 9.54E-6 | Menarche (age at onset) |
| BRCA | cis | rs7647973 | 1 | rs11710434 | chr3:49346130 | WDR6 | chr3:49044637-49053386:+ | -0.12 | -3.7 | 0.00023 | Menarche (age at onset) |
| BRCA | cis | rs11710497 | 1 | rs11710497 | chr3:11045896 | SLC6A1 | chr3:11034420-11080934:+ | 0.2 | 4.16 | 3.47E-5 | Longitudinal alcohol consumption |
| BRCA | cis | rs3749237 | 1 | rs11710675 | chr3:49751900 | CCDC36 | chr3:49235861-49295537:+ | 0.09 | 3.71 | 0.000222 | Resting heart rate |
| BRCA | cis | rs3749237 | 1 | rs11710675 | chr3:49751900 | DALRD3 | chr3:49052435-49058467:- | 0.13 | 4.52 | 6.95E-6 | Resting heart rate |
| BRCA | cis | rs3749237 | 1 | rs11710675 | chr3:49751900 | P4HTM | chr3:49027341-49044579:+ | 0.09 | 4.09 | 4.73E-5 | Resting heart rate |
| BRCA | cis | rs6441961 | 1 | rs11711054 | chr3:46345611 | FYCO1 | chr3:45959396-46037307:- | -0.11 | -3.67 | 0.000251 | Celiac disease |
| BRCA | cis | rs1171113 | 1 | rs1171112 | chr6:84226568 | PRSS35 | chr6:84222274-84235419:+ | 0.14 | 4.02 | 6.35E-5 | Bipolar disorder with mood-incongruent psychosis |
| BRCA | cis | rs1171113 | 1 | rs1171112 | chr6:84226568 | SNAP91 | chr6:84262607-84419127:- | -0.15 | -3.93 | 9.16E-5 | Bipolar disorder with mood-incongruent psychosis |
| BRCA | cis | rs1171113 | 1 | rs1171113 | chr6:84226595 | PRSS35 | chr6:84222274-84235419:+ | 0.14 | 4.02 | 6.35E-5 | Bipolar disorder with mood-incongruent psychosis |